Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
نویسندگان
چکیده
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.
منابع مشابه
Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates
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ورودعنوان ژورنال:
- Science
دوره 310 5756 شماره
صفحات -
تاریخ انتشار 2005